All for One
The Genome Canada-led All for One precision health initiative will enable a new standard of care for patients with rare diseases across Canada.
Breakthroughs in precision health, which harnesses the power of genome sequencing for diagnosis and treatment of genetic conditions, are revolutionizing healthcare. But access to clinical genomic testing is inconsistent across Canada.
The pan-Canadian All for One initiative is advancing precision health across the country, increasing equitable and timely access to accurate, genomics-enabled clinical diagnosis for Canadians with serious genetic diseases. All for One is improving the health and wellness of Canadians by building regional genomics capacity, promoting the equitable and ethical uptake of precision health tools and addressing barriers to data sharing.
As a foundational element of Genome Canada’s precision health leadership, All for One is making a major contribution to Canada’s national rare disease strategy.
The initiative is being deployed through six implementation projects, funded through the Canadian Genomics Enterprise (Genome Canada and six regional Genome Centres) as part of our Genomic Applications Partnership Program (GAPP). These projects are unified by a policy toolkit and action plan to develop a Pan-Canadian Health Data Ecosystem.
By the numbers
The $39 million All for One initiative includes $13 million in federal investment through Genome Canada and $26 million in co-funding from industry, health-care organizations, provincial and other partners brought in through six regional Genome Centres.
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Implementation projects in precision health
Building regional capacity to bring genomics into the clinic
With unequal access to clinical genomic testing across Canada, equitably resourcing and sharing best practices across regional clinical genomic testing sites is urgently needed. All for One projects are developing clinical genomic testing sites across the country, fuelled by investment through the Canadian Genomics Enterprise, as well as significant financial investment from provincial and regional health services authorities, who are critical receptors and partners for All for One.
Each project:
- Has co-funding and support from provincial and regional health services authorities responsible for clinical implementation.
- Is led by an interdisciplinary team, including clinicians, healthcare providers, researchers, health economists and other key partners helping to advance the use of genomics to improve diagnosis and treatment options.
- Is evaluated for cost-effectiveness to determine which approaches are likely to lead to better uptake from provincial and regional health authorities.
- Has committed to data sharing and maintaining relevant standards consistent with the GA4GH, IRDIRC and FAIR Guiding Principles for Scientific Data Management and Stewardship.
Active Projects
- British Columbia: Implementation of Diagnostic Whole Genome Sequencing for Rare Diseases in British Columbia
- Alberta: TIGeR: Translational Implementation of Genomics for Rare diseases
- Prairies: Canadian Prairie Metabolic Network
- Ontario: Optimization and Implementation of a Clinical Genome-Wide Sequencing Service for Rare Disease Diagnosis in Ontario
- Quebec: Rapid Whole-Genome Sequencing in Acute Care Neonates and Infants
- Atlantic Canada: Implementation of Clinical Exomes in a Pre- and Peri-Natal Setting
LEARN MORE
Press release: Genomics investments deliver precision health for Canadians (April 26, 2022)
Backgrounder: All for One: New pan-Canadian initiative will increase equitable access to genome-wide sequencing for diagnosis and treatment of genetic disease
Contact Dr. Ivana Cecić, Director, Corporate Development (Health Portfolio), for more on All for One.
Partners and Collaborators
THE CANCOGEN NETWORK IS:
VIRUSSEQ
Sequencing up to 150,000 viral samples from people testing positive for COVID-19, we hope to improve tracking of how the virus is changing and spreading, providing key data on virus transmission trends and changes in the virus that may impact viral detection or the effectiveness of treatments or vaccines.
HOSTSEQ
Sequencing the genomes of up to 10,000 patients diagnosed with COVID-19 (the “hosts”), we hope to better understand how the virus impacts individuals in different ways in hopes of better understanding patterns and trends amongst certain individuals.
GOVERNANCE
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SECTOR/MISSION PARTNERS
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NEWS & RESOURCES
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